An on the road journey with comedienne Lily Tomlin and her collaborator Jane Wagner as they mount her Tony Award-winning, one-woman show, The Search for Signs of Intelligent Life in the Universe. Breaking new comedic ground with keen satire, Lily touches and entertains while poking fun at everything from disillusioned feminists, lesbians and prostitutes, to depression, suicide and homelessness. This film is a rare, intimate view of the creative process and one of the most influential comediennes of all time.